2okj: Difference between revisions

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[[Image:2okj.gif|left|200px]]<br /><applet load="2okj" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2okj.gif|left|200px]]
caption="2okj, resolution 2.300&Aring;" />
 
'''The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67)'''<br />
{{Structure
|PDB= 2okj |SIZE=350|CAPTION= <scene name='initialview01'>2okj</scene>, resolution 2.300&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene> and <scene name='pdbligand=PLZ:4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID'>PLZ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15]
|GENE= GAD1, GAD, GAD67 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''The X-ray crystal structure of the 67kDa isoform of Glutamic Acid Decarboxylase (GAD67)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OKJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ABU:'>ABU</scene> and <scene name='pdbligand=PLZ:'>PLZ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glutamate_decarboxylase Glutamate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.15 4.1.1.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKJ OCA].  
2OKJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OKJ OCA].  


==Reference==
==Reference==
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop., Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC, Nat Struct Mol Biol. 2007 Apr;14(4):280-6. Epub 2007 Mar 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17384644 17384644]
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop., Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC, Nat Struct Mol Biol. 2007 Apr;14(4):280-6. Epub 2007 Mar 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17384644 17384644]
[[Category: Glutamate decarboxylase]]
[[Category: Glutamate decarboxylase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: plp-dependent decarboxylase]]
[[Category: plp-dependent decarboxylase]]


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