4mrq: Difference between revisions
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{{STRUCTURE_4mrq| PDB=4mrq | SCENE= }} | |||
===Crystal Structure of wild-type unphosphorylated PMM/PGM=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/ALGC_PSEAE ALGC_PSEAE]] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.<ref>PMID:7515870</ref> <ref>PMID:10481091</ref> | |||
==About this Structure== | |||
[[4mrq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRQ OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Beamer, L.]] | |||
[[Category: Lee, Y.]] | |||
[[Category: Isomerase]] | |||
Revision as of 10:38, 8 January 2014
Crystal Structure of wild-type unphosphorylated PMM/PGM
Function
[ALGC_PSEAE] The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity, and for biofilm production.[1] [2]
About this Structure
4mrq is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Coyne MJ Jr, Russell KS, Coyle CL, Goldberg JB. The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core. J Bacteriol. 1994 Jun;176(12):3500-7. PMID:7515870
- ↑ Olvera C, Goldberg JB, Sanchez R, Soberon-Chavez G. The Pseudomonas aeruginosa algC gene product participates in rhamnolipid biosynthesis. FEMS Microbiol Lett. 1999 Oct 1;179(1):85-90. PMID:10481091
