4mvt: Difference between revisions
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{{STRUCTURE_4mvt| PDB=4mvt | SCENE= }} | |||
===Crystal structure of SUMO E3 Ligase PIAS3=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PIAS3_HUMAN PIAS3_HUMAN]] Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.<ref>PMID:9388184</ref> | |||
==About this Structure== | |||
[[4mvt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MVT OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Dong, A.]] | |||
[[Category: Edwards, A M.]] | |||
[[Category: Hu, J.]] | |||
[[Category: Li, Y.]] | |||
[[Category: SGC, Structural Genomics Consortium.]] | |||
[[Category: Tempel, W.]] | |||
[[Category: Tong, Y.]] | |||
[[Category: E3 ligase]] | |||
[[Category: Ligase]] | |||
[[Category: Pinit domain]] | |||
[[Category: Sgc]] | |||
[[Category: Sp-ring domain]] | |||
[[Category: Structural genomic]] | |||
[[Category: Structural genomics consortium]] | |||
[[Category: Sumo]] | |||