4bup: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
===A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases=== | ===A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases=== | ||
{{ABSTRACT_PUBMED_24049080}} | {{ABSTRACT_PUBMED_24049080}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/SV421_MOUSE SV421_MOUSE]] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).<ref>PMID:15145825</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4bup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4bup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUP OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024049080</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024049080</ref><references group="xtra"/><references/> | ||
[[Category: Histone-lysine N-methyltransferase]] | [[Category: Histone-lysine N-methyltransferase]] | ||
[[Category: | [[Category: Lk3 transgenic mice]] | ||
[[Category: Cronin, N B.]] | [[Category: Cronin, N B.]] | ||
[[Category: Southall, S M.]] | [[Category: Southall, S M.]] | ||
