2onp: Difference between revisions

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[[Image:2onp.gif|left|200px]]<br /><applet load="2onp" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2onp.gif|left|200px]]
caption="2onp, resolution 2.000&Aring;" />
 
'''Arg475Gln Mutant of Human Mitochondrial Aldehyde Dehydrogenase, complexed with NAD+'''<br />
{{Structure
|PDB= 2onp |SIZE=350|CAPTION= <scene name='initialview01'>2onp</scene>, resolution 2.000&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=GAI:GUANIDINE'>GAI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(+)) Aldehyde dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.3 1.2.1.3]
|GENE= ALDH2, ALDM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Arg475Gln Mutant of Human Mitochondrial Aldehyde Dehydrogenase, complexed with NAD+'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2ONP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=NAD:'>NAD</scene>, <scene name='pdbligand=EDO:'>EDO</scene> and <scene name='pdbligand=GAI:'>GAI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(+)) Aldehyde dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.3 1.2.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONP OCA].  
2ONP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ONP OCA].  


==Reference==
==Reference==
Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487., Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD, J Biol Chem. 2007 Apr 27;282(17):12940-50. Epub 2007 Feb 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17327228 17327228]
Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487., Larson HN, Zhou J, Chen Z, Stamler JS, Weiner H, Hurley TD, J Biol Chem. 2007 Apr 27;282(17):12940-50. Epub 2007 Feb 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17327228 17327228]
[[Category: Aldehyde dehydrogenase (NAD(+))]]
[[Category: Aldehyde dehydrogenase (NAD(+))]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: rossman fold]]
[[Category: rossman fold]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:20:37 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:02:06 2008''
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