2op9: Difference between revisions

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[[Image:2op9.gif|left|200px]]<br /><applet load="2op9" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2op9.gif|left|200px]]
caption="2op9, resolution 1.800&Aring;" />
 
'''Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus'''<br />
{{Structure
|PDB= 2op9 |SIZE=350|CAPTION= <scene name='initialview01'>2op9</scene>, resolution 1.800&Aring;
|SITE= <scene name='pdbsite=AC1:Wr1+Binding+Site+For+Residue+A+601'>AC1</scene> and <scene name='pdbsite=AC2:Wr1+Binding+Site+For+Residue+B+602'>AC2</scene>
|LIGAND= <scene name='pdbligand=WR1:NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE'>WR1</scene>
|ACTIVITY=
|GENE= 3Clpro ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])
}}
 
'''Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OP9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus] with <scene name='pdbligand=WR1:'>WR1</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Wr1+Binding+Site+For+Residue+A+601'>AC1</scene> and <scene name='pdbsite=AC2:Wr1+Binding+Site+For+Residue+B+602'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OP9 OCA].  
2OP9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OP9 OCA].  


==Reference==
==Reference==
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus., Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS, Biochemistry. 2007 Jul 31;46(30):8744-52. Epub 2007 Jul 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17605471 17605471]
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus., Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS, Biochemistry. 2007 Jul 31;46(30):8744-52. Epub 2007 Jul 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17605471 17605471]
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protease]]
[[Category: protease]]
[[Category: proteinase]]
[[Category: proteinase]]
[[Category: sars]]
[[Category: sar]]


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