4c8a: Difference between revisions
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{{STRUCTURE_4c8a| PDB=4c8a | SCENE= }} | |||
===mouse ZNRF3 ectodomain crystal form II=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref> | |||
==About this Structure== | |||
[[4c8a]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8A OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Jones, E Y.]] | |||
[[Category: Zebisch, M.]] | |||
[[Category: Lgr4]] | |||
[[Category: Lgr5]] | |||
[[Category: Lgr6]] | |||
[[Category: Ligase]] | |||
[[Category: Membrane]] | |||
[[Category: R-spo]] | |||
[[Category: R-spondin]] | |||
[[Category: Receptor]] | |||
[[Category: Rnf43]] | |||
[[Category: Rspo]] | |||
[[Category: Rspo1]] | |||
[[Category: Rspo2]] | |||
[[Category: Rspo3]] | |||
[[Category: Rspo4]] | |||
[[Category: Signalling]] | |||
[[Category: Wnt]] | |||
