4c8b: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of the kinase domain of human RIPK2 in complex with ponatinib===

The ~~entry 4c8b~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/RIPK2_HUMAN RIPK2_HUMAN]] Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.<ref>PMID:14638696</ref> <ref>PMID:17054981</ref> <ref>PMID:18079694</ref> <ref>PMID:21123652</ref>

~~Authors~~: ~~Canning, P~~.~~, Krojer, T~~.~~, Bradley, A~~.~~, Mahajan, P., Goubin, S., von Delft, F., Arrowsmith, C.H., Edwards, A~~.M.~~, Bountra, C~~.~~, Bullock, A~~.

==About this Structure==

[[4c8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8B OCA].

~~Description~~: ~~Structure of the kinase domain of human RIPK2 in complex with ponatinib~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

[[Category: Bradley, A.]]

[[Category: Bullock, A.]]

[[Category: Canning, P.]]

[[Category: Delft, F von.]]

[[Category: Edwards, A M.]]

[[Category: Goubin, S.]]

[[Category: Krojer, T.]]

[[Category: Mahajan, P.]]

[[Category: Structural genomic]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4c8b|  PDB=4c8b  |  SCENE=  }}
+===Structure of the kinase domain of human RIPK2 in complex with ponatinib===
-The entry 4c8b is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/RIPK2_HUMAN RIPK2_HUMAN]] Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.<ref>PMID:14638696</ref> <ref>PMID:17054981</ref> <ref>PMID:18079694</ref> <ref>PMID:21123652</ref>
-Authors: Canning, P., Krojer, T., Bradley, A., Mahajan, P., Goubin, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
+==About this Structure==
+[[4c8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8B OCA].
-Description: Structure of the kinase domain of human RIPK2 in complex with ponatinib
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Arrowsmith, C H.]]
+[[Category: Bountra, C.]]
+[[Category: Bradley, A.]]
+[[Category: Bullock, A.]]
+[[Category: Canning, P.]]
+[[Category: Delft, F von.]]
+[[Category: Edwards, A M.]]
+[[Category: Goubin, S.]]
+[[Category: Krojer, T.]]
+[[Category: Mahajan, P.]]
+[[Category: Structural genomic]]
+[[Category: Transferase]]