2ow3: Difference between revisions

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New page: left|200px<br /><applet load="2ow3" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ow3, resolution 2.80Å" /> '''Glycogen synthase ki...
 
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[[Image:2ow3.jpg|left|200px]]<br /><applet load="2ow3" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ow3.jpg|left|200px]]
caption="2ow3, resolution 2.80&Aring;" />
 
'''Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor'''<br />
{{Structure
|PDB= 2ow3 |SIZE=350|CAPTION= <scene name='initialview01'>2ow3</scene>, resolution 2.80&Aring;
|SITE= <scene name='pdbsite=AC1:Bim+Binding+Site+For+Residue+A+387'>AC1</scene> and <scene name='pdbsite=AC2:Bim+Binding+Site+For+Residue+B+387'>AC2</scene>
|LIGAND= <scene name='pdbligand=BIM:'>BIM</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26]
|GENE= GSK3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OW3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BIM:'>BIM</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/[Tau_protein]_kinase [Tau protein] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.26 2.7.11.26] Known structural/functional Sites: <scene name='pdbsite=AC1:Bim+Binding+Site+For+Residue+A+387'>AC1</scene> and <scene name='pdbsite=AC2:Bim+Binding+Site+For+Residue+B+387'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW3 OCA].  
2OW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW3 OCA].  


==Reference==
==Reference==
Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3., Zhang HC, Bonaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE, Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17350261 17350261]
Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3., Zhang HC, Bonaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE, Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. Epub 2007 Feb 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17350261 17350261]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]


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