2ow0: Difference between revisions

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[[Image:2ow0.jpg|left|200px]]<br /><applet load="2ow0" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ow0.jpg|left|200px]]
caption="2ow0, resolution 2.00&Aring;" />
 
'''MMP-9 active site mutant with iodine-labeled carboxylate inhibitor'''<br />
{{Structure
|PDB= 2ow0 |SIZE=350|CAPTION= <scene name='initialview01'>2ow0</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=6MR:N-[(4'-IODOBIPHENYL-4-YL)SULFONYL]-D-TRYPTOPHAN'>6MR</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Gelatinase_B Gelatinase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.35 3.4.24.35]
|GENE= MMP9, CLG4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''MMP-9 active site mutant with iodine-labeled carboxylate inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OW0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=6MR:'>6MR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_B Gelatinase B], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.35 3.4.24.35] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW0 OCA].  
2OW0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OW0 OCA].  


==Reference==
==Reference==
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity., Tochowicz A, Maskos K, Huber R, Oltenfreiter R, Dive V, Yiotakis A, Zanda M, Bode W, Goettig P, J Mol Biol. 2007 Aug 24;371(4):989-1006. Epub 2007 May 31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17599356 17599356]
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity., Tochowicz A, Maskos K, Huber R, Oltenfreiter R, Dive V, Yiotakis A, Zanda M, Bode W, Goettig P, J Mol Biol. 2007 Aug 24;371(4):989-1006. Epub 2007 May 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17599356 17599356]
[[Category: Gelatinase B]]
[[Category: Gelatinase B]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: s1-prime pocket]]
[[Category: s1-prime pocket]]


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