2ozl: Difference between revisions

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[[Image:2ozl.jpg|left|200px]]<br /><applet load="2ozl" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2ozl.jpg|left|200px]]
caption="2ozl, resolution 1.90&Aring;" />
 
'''Human pyruvate dehydrogenase S264E variant'''<br />
{{Structure
|PDB= 2ozl |SIZE=350|CAPTION= <scene name='initialview01'>2ozl</scene>, resolution 1.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene> and <scene name='pdbligand=TPP:THIAMINE DIPHOSPHATE'>TPP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(acetyl-transferring) Pyruvate dehydrogenase (acetyl-transferring)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.4.1 1.2.4.1]
|GENE= PDHA1, PHE1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PDHB, PHE1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Human pyruvate dehydrogenase S264E variant'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2OZL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=TPP:'>TPP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(acetyl-transferring) Pyruvate dehydrogenase (acetyl-transferring)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.4.1 1.2.4.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OZL OCA].  
2OZL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OZL OCA].  


==Reference==
==Reference==
Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex., Seifert F, Ciszak E, Korotchkina L, Golbik R, Spinka M, Dominiak P, Sidhu S, Brauer J, Patel MS, Tittmann K, Biochemistry. 2007 May 29;46(21):6277-87. Epub 2007 May 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17474719 17474719]
Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex., Seifert F, Ciszak E, Korotchkina L, Golbik R, Spinka M, Dominiak P, Sidhu S, Brauer J, Patel MS, Tittmann K, Biochemistry. 2007 May 29;46(21):6277-87. Epub 2007 May 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17474719 17474719]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: pyruvate_dehydrogenase_complex; human; e1; multienzyme_complex_component; thiamine_pyrophosphate; thiamin_diphosphate; heterotetrameric; lipoyl_substrate; pyruvate; dihydrolipoamide_acetyltransferase; dihydrolipoamide_dehydrogenase;]]
[[Category: pyruvate_dehydrogenase_complex; human; e1; multienzyme_complex_component; thiamine_pyrophosphate; thiamin_diphosphate; heterotetrameric; lipoyl_substrate; pyruvate; dihydrolipoamide_acetyltransferase; dihydrolipoamide_dehydrogenase;]]


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