4m9s: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4m9s|  PDB=4m9s  |  SCENE=  }}
===crystal structure of CED-4 bound CED-3 fragment===
{{ABSTRACT_PUBMED_24065769}}


The entry 4m9s is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/CED4_CAEEL CED4_CAEEL]] Isoform a plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Isoform b prevents PCD.<ref>PMID:1286611</ref> <ref>PMID:8706125</ref> <ref>PMID:9027313</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref>  


Authors: Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
==About this Structure==
[[4m9s]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9S OCA].  


Description: crystal structure of CED-4 bound CED-3 fragment
==Reference==
<ref group="xtra">PMID:024065769</ref><references group="xtra"/><references/>
[[Category: Caenorhabditis elegans]]
[[Category: Choi, W Y.]]
[[Category: Huang, W J.]]
[[Category: Jinag, T Y.]]
[[Category: Shi, Y G.]]
[[Category: Wang, J W.]]
[[Category: Apoptosis]]
[[Category: Apoptosome]]
[[Category: Ced-3]]

Revision as of 06:42, 23 October 2013

Template:STRUCTURE 4m9s

crystal structure of CED-4 bound CED-3 fragment

Template:ABSTRACT PUBMED 24065769

Function

[CED4_CAEEL] Isoform a plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Isoform b prevents PCD.[1] [2] [3] [4] [5]

About this Structure

4m9s is a 8 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

  1. Huang W, Jiang T, Choi W, Qi S, Pang Y, Hu Q, Xu Y, Gong X, Jeffrey PD, Wang J, Shi Y. Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev. 2013 Sep 15;27(18):2039-48. doi: 10.1101/gad.224428.113. PMID:24065769 doi:https://dx.doi.org/10.1101/gad.224428.113
  1. ↑ Yuan J, Horvitz HR. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development. 1992 Oct;116(2):309-20. PMID:1286611
  2. ↑ Shaham S, Horvitz HR. An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell. 1996 Jul 26;86(2):201-8. PMID:8706125
  3. ↑ Wu D, Wallen HD, Nunez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science. 1997 Feb 21;275(5303):1126-9. PMID:9027313
  4. ↑ Chen F, Hersh BM, Conradt B, Zhou Z, Riemer D, Gruenbaum Y, Horvitz HR. Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science. 2000 Feb 25;287(5457):1485-9. PMID:10688797
  5. ↑ Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Mol Cell. 2004 Sep 24;15(6):999-1006. PMID:15383288 doi:10.1016/j.molcel.2004.08.022

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