4m9y: Difference between revisions
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{{STRUCTURE_4m9y| PDB=4m9y | SCENE= }} | |||
===Crystal structure of CED-4 bound CED-3 fragment=== | |||
{{ABSTRACT_PUBMED_24065769}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CED4_CAEEL CED4_CAEEL]] Isoform a plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Isoform b prevents PCD.<ref>PMID:1286611</ref> <ref>PMID:8706125</ref> <ref>PMID:9027313</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref> | |||
==About this Structure== | |||
[[4m9y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9Y OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024065769</ref><references group="xtra"/><references/> | |||
[[Category: Caenorhabditis elegans]] | |||
[[Category: Choi, W Y.]] | |||
[[Category: Huang, W J.]] | |||
[[Category: Jinag, T Y.]] | |||
[[Category: Shi, Y G.]] | |||
[[Category: Wang, J W.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Apoptosome]] | |||