4mr3: Difference between revisions
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{{STRUCTURE_4mr3| PDB=4mr3 | SCENE= }} | |||
===Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)=== | |||
{{ABSTRACT_PUBMED_24248379}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[4mr3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024248379</ref><references group="xtra"/><references/> | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Delft, F von.]] | |||
[[Category: Edwards, A M.]] | |||
[[Category: Fedorov, O.]] | |||
[[Category: Felletar, I.]] | |||
[[Category: Filippakopoulos, P.]] | |||
[[Category: Knapp, S.]] | |||
[[Category: Martin, S.]] | |||
[[Category: Picaud, S.]] | |||
[[Category: Weigelt, J.]] | |||
[[Category: Brd]] | |||
[[Category: Brd4]] | |||
[[Category: Cap]] | |||
[[Category: Hunk1]] | |||
[[Category: Mcap]] | |||
[[Category: Mitotic chromosome associated protein]] | |||
[[Category: Rvx-oh]] | |||
[[Category: Sgc]] | |||
[[Category: Small molecule inhibitor]] | |||
[[Category: Structural genomics consortium]] | |||
[[Category: Transcription-transcription inhibitor complex]] | |||
Revision as of 10:20, 27 November 2013
Crystal Structure of the first bromodomain of human BRD4 in complex with a quinazolinone ligand (RVX-OH)
Template:ABSTRACT PUBMED 24248379
Disease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]
Function
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this Structure
4mr3 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Picaud S, Wells C, Felletar I, Brotherton D, Martin S, Savitsky P, Diez-Dacal B, Philpott M, Bountra C, Lingard H, Fedorov O, Muller S, Brennan PE, Knapp S, Filippakopoulos P. RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc Natl Acad Sci U S A. 2013 Nov 18. PMID:24248379 doi:https://dx.doi.org/10.1073/pnas.1310658110
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0
