2p41: Difference between revisions

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[[Image:2p41.jpg|left|200px]]<br /><applet load="2p41" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2p41.jpg|left|200px]]
caption="2p41, resolution 1.801&Aring;" />
 
'''Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine'''<br />
{{Structure
|PDB= 2p41 |SIZE=350|CAPTION= <scene name='initialview01'>2p41</scene>, resolution 1.801&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=G1G:7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-GUANOSINE'>G1G</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]
|GENE= NSP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11070 Dengue virus type 4])
}}
 
'''Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2P41 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_4 Dengue virus type 4] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=G1G:'>G1G</scene>, <scene name='pdbligand=SAH:'>SAH</scene>, <scene name='pdbligand=CIT:'>CIT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P41 OCA].  
2P41 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_type_4 Dengue virus type 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P41 OCA].  


==Reference==
==Reference==
Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5., Egloff MP, Decroly E, Malet H, Selisko B, Benarroch D, Ferron F, Canard B, J Mol Biol. 2007 Sep 21;372(3):723-36. Epub 2007 Jul 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17686489 17686489]
Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5., Egloff MP, Decroly E, Malet H, Selisko B, Benarroch D, Ferron F, Canard B, J Mol Biol. 2007 Sep 21;372(3):723-36. Epub 2007 Jul 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17686489 17686489]
[[Category: Dengue virus type 4]]
[[Category: Dengue virus type 4]]
[[Category: RNA-directed RNA polymerase]]
[[Category: RNA-directed RNA polymerase]]
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[[Category: vizier; viral enzymes involved in replication; dengue virus methyltransferase; structural genomics; marseilles structural genomics program @ afmb; msgp]]
[[Category: vizier; viral enzymes involved in replication; dengue virus methyltransferase; structural genomics; marseilles structural genomics program @ afmb; msgp]]


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