2p83: Difference between revisions

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[[Image:2p83.jpg|left|200px]]<br /><applet load="2p83" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2p83.jpg|left|200px]]
caption="2p83, resolution 2.500&Aring;" />
 
'''Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1'''<br />
{{Structure
|PDB= 2p83 |SIZE=350|CAPTION= <scene name='initialview01'>2p83</scene>, resolution 2.500&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> and <scene name='pdbligand=MR0:N~3~-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-N~1~,N~1~-DIPROPYLBENZENE-1,3,5-TRICARBOXAMIDE'>MR0</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46]
|GENE= BACE1, BACE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2P83 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> and <scene name='pdbligand=MR0:'>MR0</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P83 OCA].  
2P83 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P83 OCA].  


==Reference==
==Reference==
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1., Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. Epub 2007 Apr 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17434734 17434734]
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1., Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. Epub 2007 Apr 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17434734 17434734]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
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[[Category: protein-inhibitor complex]]
[[Category: protein-inhibitor complex]]


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