4mgp: Difference between revisions
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==Structure of racemic Ala-(8,13,18) Magainin 2== | |||
<StructureSection load='4mgp' size='340' side='right' caption='[[4mgp]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4mgp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MGP FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mag|2mag]], [[1dum|1dum]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mgp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mgp RCSB], [http://www.ebi.ac.uk/pdbsum/4mgp PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
High-resolution structure elucidation has been challenging for the large group of host-defense peptides that form helices on or within membranes but do not manifest a strong folding propensity in aqueous solution. Here we report the crystal structure of an analogue of the widely studied host-defense peptide magainin 2. Magainin 2 (S8A, G13A, G18A) is a designed variant that displays enhanced antibacterial activity relative to the natural peptide. The crystal structure of magainin 2 (S8A, G13A, G18A), obtained for the racemic form, features a dimerization mode that has previously been proposed to play a role in the antibacterial activity of magainin 2 and related peptides. | |||
Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-ray Crystal Structure of a Magainin 2 Analogue.,Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH J Am Chem Soc. 2013 Oct 8. PMID:24102563<ref>PMID:24102563</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: Forest, K T | </StructureSection> | ||
[[Category: Gellman, S H | [[Category: Forest, K T]] | ||
[[Category: Hayouka, Z | [[Category: Gellman, S H]] | ||
[[Category: Kreitler, D F | [[Category: Hayouka, Z]] | ||
[[Category: Mortenson, D E | [[Category: Kreitler, D F]] | ||
[[Category: Weisblum, B | [[Category: Mortenson, D E]] | ||
[[Category: Weisblum, B]] | |||
[[Category: Antimicrobial protein]] | [[Category: Antimicrobial protein]] | ||
[[Category: Phenylalanine zipper]] | [[Category: Phenylalanine zipper]] | ||
Revision as of 08:30, 8 December 2014
Structure of racemic Ala-(8,13,18) Magainin 2
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