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{{STRUCTURE_4ja0|  PDB=4ja0  |  SCENE=  }}
==Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution==
===Crystal structure of the invertebrate bi-functional purine biosynthesis enzyme PAICS at 2.8 A resolution===
<StructureSection load='4ja0' size='340' side='right' caption='[[4ja0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
{{ABSTRACT_PUBMED_23553965}}
== Structural highlights ==
<table><tr><td colspan='2'>[[4ja0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JA0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ja0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ja0 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Two important steps of the de novo purine biosynthesis pathway are catalyzed by the 5-aminoimidazole ribonucleotide carboxylase and the 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase enzymes. In most eukaryotic organisms, these two activities are present in the bifunctional enzyme complex known as PAICS. We have determined the 2.8-A resolution crystal structure of the 350-kDa invertebrate PAICS from insect cells (Trichoplusia ni) using single-wavelength anomalous dispersion methods. Comparison of insect PAICS to human and prokaryotic homologs provides insights into substrate binding and reveals a highly conserved enzymatic framework across divergent species.


==About this Structure==
Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 A resolution.,Taschner M, Basquin J, Benda C, Lorentzen E Proteins. 2013 Aug;81(8):1473-8. doi: 10.1002/prot.24296. Epub 2013 Jun 1. PMID:23553965<ref>PMID:23553965</ref>
[[4ja0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA0 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:023553965</ref><references group="xtra"/><references/>
</div>
 
==See Also==
*[[Phosphoribosylaminoimidazole carboxylase|Phosphoribosylaminoimidazole carboxylase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bombyx mori]]
[[Category: Bombyx mori]]
[[Category: Basquin, J.]]
[[Category: Basquin, J]]
[[Category: Benda, C.]]
[[Category: Benda, C]]
[[Category: Lorentzen, E.]]
[[Category: Lorentzen, E]]
[[Category: Taschner, M.]]
[[Category: Taschner, M]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Purine biosynthesis]]
[[Category: Purine biosynthesis]]
[[Category: Saicar pure]]
[[Category: Saicar pure]]
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