4cb9: Difference between revisions
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{{STRUCTURE_4cb9| PDB=4cb9 | SCENE= }} | |||
===Structure of full-length CTNNBL1 in P43212 space group=== | |||
{{ABSTRACT_PUBMED_24269683}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref> | |||
==About this Structure== | |||
[[4cb9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB9 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024269683</ref><references group="xtra"/><references/> | |||
[[Category: Ganesh, K.]] | |||
[[Category: Johnson, C M.]] | |||
[[Category: Neuberger, M S.]] | |||
[[Category: Rada, C.]] | |||
[[Category: Simpson, P.]] | |||
[[Category: Telerman, S B.]] | |||
[[Category: Williams, R L.]] | |||
[[Category: VanMaldegem, F.]] | |||
[[Category: Aid]] | |||
[[Category: Apoptosis]] | |||
[[Category: Deaminase]] | |||
[[Category: Import]] | |||
Revision as of 07:18, 4 December 2013
Structure of full-length CTNNBL1 in P43212 space group
Template:ABSTRACT PUBMED 24269683
Function
[CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.[1] [2]
About this Structure
4cb9 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Ganesh K, van Maldegem F, Telerman SB, Simpson P, Johnson CM, Williams RL, Neuberger MS, Rada C. Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha FEBS Lett. 2013 Nov 20. pii: S0014-5793(13)00847-8. doi:, 10.1016/j.febslet.2013.11.013. PMID:24269683 doi:https://dx.doi.org/10.1016/j.febslet.2013.11.013
- ↑ Jabbour L, Welter JF, Kollar J, Hering TM. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics. 2003 Mar;81(3):292-303. PMID:12659813
- ↑ Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell. 2008 Aug 22;31(4):474-84. doi: 10.1016/j.molcel.2008.07.009. PMID:18722174 doi:10.1016/j.molcel.2008.07.009
