4g32: Difference between revisions
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{{STRUCTURE_4g32| PDB=4g32 | SCENE= }} | |||
===Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 1.75A (P21212)=== | |||
{{ABSTRACT_PUBMED_23985801}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LOX_PSEAI LOX_PSEAI]] In presence of oxygen, converts oleic acid into (S)-(E)-10-hydroperoxy-8-octadecenoic acid (HPOD), which spontaneously decomposes to the corresponding (E)-10-hydroxy-8-octadecenoic acid (HOD). In vivo, the reaction leads to the dihydroxy derivative (E)-7,10-dihydroxy-8-octadecenoic acid (DHOD), so that the three hydroxy-fatty acids can be isolated from the culture medium. Also active on linoleic acid and linolenic acid. Almost not active on arachidonic acid. | |||
==About this Structure== | |||
[[4g32]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G32 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023985801</ref><references group="xtra"/><references/> | |||
[[Category: Pseudomonas aeruginosa]] | |||
[[Category: Carpena, X.]] | |||
[[Category: Fita, I.]] | |||
[[Category: Garcia-Fernandez, Q.]] | |||
[[Category: Garreta, A.]] | |||
[[Category: Val-Moraes, S P.]] | |||
[[Category: Non-heme iron enzyme]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Protein-phospholipid complex]] | |||
Revision as of 07:39, 6 November 2013
Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 1.75A (P21212)
Template:ABSTRACT PUBMED 23985801
Function
[LOX_PSEAI] In presence of oxygen, converts oleic acid into (S)-(E)-10-hydroperoxy-8-octadecenoic acid (HPOD), which spontaneously decomposes to the corresponding (E)-10-hydroxy-8-octadecenoic acid (HOD). In vivo, the reaction leads to the dihydroxy derivative (E)-7,10-dihydroxy-8-octadecenoic acid (DHOD), so that the three hydroxy-fatty acids can be isolated from the culture medium. Also active on linoleic acid and linolenic acid. Almost not active on arachidonic acid.
About this Structure
4g32 is a 1 chain structure with sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
- Garreta A, Val-Moraes SP, Garcia-Fernandez Q, Busquets M, Juan C, Oliver A, Ortiz A, Gaffney BJ, Fita I, Manresa A, Carpena X. Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa. FASEB J. 2013 Aug 30. PMID:23985801 doi:https://dx.doi.org/10.1096/fj.13-235952
