4luw: Difference between revisions
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{{STRUCTURE_4luw| PDB=4luw | SCENE= }} | {{STRUCTURE_4luw| PDB=4luw | SCENE= }} | ||
===Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine=== | ===Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine=== | ||
{{ABSTRACT_PUBMED_24145412}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4luw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LUW OCA]. | [[4luw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LUW OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024145412</ref><references group="xtra"/><references/> | |||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
Revision as of 06:18, 6 November 2013
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine
Template:ABSTRACT PUBMED 24145412
Function
[NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
About this Structure
4luw is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
- Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL. Structural and biological studies on bacterial nitric oxide synthase inhibitors. Proc Natl Acad Sci U S A. 2013 Oct 21. PMID:24145412 doi:https://dx.doi.org/10.1073/pnas.1314080110
