4al9: Difference between revisions
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==Crystal structure of the lectin PA-IL from Pseudomonas aeruginoas in complex with melibiose== | |||
<StructureSection load='4al9' size='340' side='right' caption='[[4al9]], [[Resolution|resolution]] 1.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4al9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AL9 FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene><br> | |||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l7l|1l7l]], [[1oko|1oko]], [[1uoj|1uoj]], [[2vxj|2vxj]], [[2wyf|2wyf]], [[3zyb|3zyb]], [[3zyf|3zyf]], [[3zyh|3zyh]], [[4a6s|4a6s]]</td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4al9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4al9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4al9 RCSB], [http://www.ebi.ac.uk/pdbsum/4al9 PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The galactose-specific lectin LecA from Pseudomonas aeruginosa is a target for the development of new anti-infectious compounds. Sugar based molecules with anti-adhesive properties present great potential in the fight against bacterial infection and biofilm formation. LecA is specific for oligosaccharides with terminal alpha-galactoside residues and displays strong affinity for melibiose (alphaGal1-6Glc) with a Kd of 38.8 microM. The crystal structure of LecA/melibiose complex shows classical calcium-bridged binding of alphaGal in the primary binding site but also revealed a secondary sugar binding site with glucose bound. This sugar binding site is in close proximity to the galactose binding one, is independent of calcium and mainly involves interactions with a symmetry-related protein. This discovery would help to the design of new potent inhibitors targeting both binding sites. | |||
Secondary sugar binding site identified for LecA lectin from Pseudomonas aeruginosa.,Blanchard B, Imberty A, Varrot A Proteins. 2013 Oct 1. doi: 10.1002/prot.24430. PMID:24123124<ref>PMID:24123124</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Pseae]] | |||
[[Category: Blanchard, B.]] | [[Category: Blanchard, B.]] | ||
[[Category: Imberty, A.]] | [[Category: Imberty, A.]] | ||
Revision as of 07:07, 28 May 2014
Crystal structure of the lectin PA-IL from Pseudomonas aeruginoas in complex with melibiose
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