Ku protein: Difference between revisions
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=== DNA binding ring === | === DNA binding ring === | ||
The <scene name='56/567269/Ku70_dimer/6'>DNA binding ring</scene> on the open end of DNA is associated with the | The <scene name='56/567269/Ku70_dimer/6'>DNA binding ring</scene> on the open end of DNA is associated with the Ku70 subunit. | ||
By binding | By binding DNA, Ku realigns the the strands and protects the molecule from degradation and unwanted bonds while NHEJ occurs.<ref name="Walker"/> | ||
The regulation of the DNA binding ring of Ku is still under research, with data supporting oxidative stress and redox reactions decreasing the association of the | The regulation of the DNA binding ring of Ku is still under research, with data supporting oxidative stress and redox reactions decreasing the association of the Ku heterodimer with bound DNA through alterations in cysteine residues on the Ku70 subunit [[NEED SCENE OF CYSTEINES]]. <ref name="source3"/> <ref name="source4"> PMID: 14585978</ref> | ||
