2pot: Difference between revisions

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[[Image:2pot.gif|left|200px]]<br /><applet load="2pot" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2pot.gif|left|200px]]
caption="2pot, resolution 1.8&Aring;" />
 
'''tRNA guanine transglycosylase (TGT) E235Q mutant in complex with guanine'''<br />
{{Structure
|PDB= 2pot |SIZE=350|CAPTION= <scene name='initialview01'>2pot</scene>, resolution 1.8&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Queuine_tRNA-ribosyltransferase Queuine tRNA-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29]
|GENE= tgt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=542 Zymomonas mobilis])
}}
 
'''tRNA guanine transglycosylase (TGT) E235Q mutant in complex with guanine'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2POT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=GUN:'>GUN</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Queuine_tRNA-ribosyltransferase Queuine tRNA-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POT OCA].  
2POT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis Zymomonas mobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2POT OCA].  


==Reference==
==Reference==
Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies., Tidten N, Stengl B, Heine A, Garcia GA, Klebe G, Reuter K, J Mol Biol. 2007 Nov 30;374(3):764-76. Epub 2007 Oct 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17949745 17949745]
Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies., Tidten N, Stengl B, Heine A, Garcia GA, Klebe G, Reuter K, J Mol Biol. 2007 Nov 30;374(3):764-76. Epub 2007 Oct 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17949745 17949745]
[[Category: Queuine tRNA-ribosyltransferase]]
[[Category: Queuine tRNA-ribosyltransferase]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase]]
[[Category: transferase]]


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