4cbt: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4cbt|  PDB=4cbt  |  SCENE=  }}
===Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntingtons disease===
{{ABSTRACT_PUBMED_24261862}}


The entry 4cbt is ON HOLD until Paper Publication
==Disease==
[[http://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN]] Defects in HDAC4 are the cause of brachydactyly-mental retardation syndrome (BDMR) [MIM:[http://omim.org/entry/600430 600430]]. A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.<ref>PMID:20691407</ref>  


Authors: Burli, R.W., Luckhurst, C.A., Aziz, O., Matthews, K.L., Yates, D., Lyons, K.A., Beconi, M., McAllister, G., Breccia, P., Stott, A.J., Penrose, S.D., Wall, M., Lamers, M., Leonard, P., Mueller, I., Richardson, C.M., Jarvis, R., Stones, L., Hughes, S., Wishart, G., Haughan, A.F., OConnell, C., Mead, T., McNeil, H., Vann, J., Mangette, J., Maillard, M., Beaumont, V., Munoz-Sanjuan, I., Dominguez, C.
==Function==
[[http://www.uniprot.org/uniprot/HDAC4_HUMAN HDAC4_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.<ref>PMID:10523670</ref> 


Description: Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntingtons disease
==About this Structure==
[[4cbt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBT OCA].
 
==Reference==
<ref group="xtra">PMID:024261862</ref><references group="xtra"/><references/>
[[Category: Histone deacetylase]]
[[Category: Aziz, O.]]
[[Category: Beaumont, V.]]
[[Category: Beconi, M.]]
[[Category: Breccia, P.]]
[[Category: Burli, R W.]]
[[Category: Dominguez, C.]]
[[Category: Haughan, A F.]]
[[Category: Hughes, S.]]
[[Category: Jarvis, R.]]
[[Category: Lamers, M.]]
[[Category: Leonard, P.]]
[[Category: Luckhurst, C A.]]
[[Category: Lyons, K A.]]
[[Category: Maillard, M.]]
[[Category: Mangette, J.]]
[[Category: Matthews, K L.]]
[[Category: McAllister, G.]]
[[Category: McNeil, H.]]
[[Category: Mead, T.]]
[[Category: Mueller, I.]]
[[Category: Munoz-Sanjuan, I.]]
[[Category: OConnell, C.]]
[[Category: Penrose, S D.]]
[[Category: Richardson, C M.]]
[[Category: Stones, L.]]
[[Category: Stott, A J.]]
[[Category: Vann, J.]]
[[Category: Wall, M.]]
[[Category: Wishart, G.]]
[[Category: Yates, D.]]
[[Category: Amyotrophic lateral sclerosis]]
[[Category: Class iia histone deacetylase inhibitor]]
[[Category: Cyclopropanation]]
[[Category: Huntingtons disease]]
[[Category: Hydrolase]]
[[Category: Hydroxamic acid]]
[[Category: Muscle atrophy]]
[[Category: Neurodegeneration]]
[[Category: Sar]]
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