4hne: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP===

The ~~entry 4hne~~ is ~~ON HOLD until Apr 18 2015~~

==Function==

[[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.

~~Authors~~: ~~Zhou, Q., Zhai, Y~~.~~, Zhang, K~~.~~, Chen, C~~.~~, Sun, F~~.

==About this Structure==

[[4hne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNE OCA].

~~Description~~: ~~Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol~~ 4-kinase ~~(PI4KIIalpha) in complex with ADP~~

==Reference==

[[Category: 1-phosphatidylinositol 4-kinase]]

[[Category: Chen, C.]]

[[Category: Sun, F.]]

[[Category: Zhai, Y.]]

[[Category: Zhang, K.]]

[[Category: Zhou, Q.]]

[[Category: Atp binding]]

[[Category: Lipid kinase]]

[[Category: Membrane anchoring]]

[[Category: Palmitoylation]]

[[Category: Pi3k/pi4k kinase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4hne|  PDB=4hne  |  SCENE=  }}
+===Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP===
+{{ABSTRACT_PUBMED_24675427}}
-The entry 4hne is ON HOLD  until Apr 18 2015
+==Function==
+[[http://www.uniprot.org/uniprot/P4K2A_HUMAN P4K2A_HUMAN]] Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.
-Authors: Zhou, Q., Zhai, Y., Zhang, K., Chen, C., Sun, F.
+==About this Structure==
+[[4hne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HNE OCA].
-Description: Crystal structure of the catalytic domain of human type II alpha Phosphatidylinositol 4-kinase (PI4KIIalpha) in complex with ADP
+==Reference==
+<ref group="xtra">PMID:024675427</ref><references group="xtra"/><references/>
+[[Category: 1-phosphatidylinositol 4-kinase]]
+[[Category: Chen, C.]]
+[[Category: Sun, F.]]
+[[Category: Zhai, Y.]]
+[[Category: Zhang, K.]]
+[[Category: Zhou, Q.]]
+[[Category: Atp binding]]
+[[Category: Lipid kinase]]
+[[Category: Membrane anchoring]]
+[[Category: Palmitoylation]]
+[[Category: Pi3k/pi4k kinase]]
+[[Category: Transferase]]