4m9f: Difference between revisions
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{{STRUCTURE_4m9f| PDB=4m9f | SCENE= }} | |||
===Dengue virus NS2B-NS3 protease A125C variant at pH 8.5=== | |||
{{ABSTRACT_PUBMED_24164286}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | |||
==About this Structure== | |||
[[4m9f]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9F OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024164286</ref><references group="xtra"/><references/> | |||
[[Category: Bell, J A.]] | |||
[[Category: Ghosh, S.]] | |||
[[Category: Hardy, J A.]] | |||
[[Category: Sherman, W.]] | |||
[[Category: Yildiz, M.]] | |||
[[Category: Allosteric inhibition]] | |||
[[Category: Conformational flexibility]] | |||
[[Category: Dengue virus protease]] | |||
[[Category: Serine protease]] | |||
[[Category: Trypsin-like protease]] | |||
[[Category: Viral protein]] | |||
Revision as of 10:19, 27 November 2013
Dengue virus NS2B-NS3 protease A125C variant at pH 8.5
Template:ABSTRACT PUBMED 24164286
Function
[Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
About this Structure
4m9f is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Yildiz M, Ghosh S, Bell JA, Sherman W, Hardy JA. Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus. ACS Chem Biol. 2013 Oct 28. PMID:24164286 doi:https://dx.doi.org/10.1021/cb400612h
