4mgt: Difference between revisions
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{{STRUCTURE_4mgt| PDB=4mgt | SCENE= }} | |||
===ALKBH2 R110A cross-linked to undamaged dsDNA=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref> | |||
==About this Structure== | |||
[[4mgt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MGT OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: DNA oxidative demethylase]] | |||
[[Category: Chen, B.]] | |||
[[Category: Gan, J.]] | |||
[[Category: Yang, C G.]] | |||
[[Category: Oxidoreductase-dna complex]] | |||
[[Category: Protein-dna complex]] | |||