4mqq: Difference between revisions
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{{STRUCTURE_4mqq| PDB=4mqq | SCENE= }} | |||
===Mycobaterium tuberculosis transaminase BioA complexed with benzo[d]thiazole-2-carbohydrazide=== | |||
{{ABSTRACT_PUBMED_24482078}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BIOA_MYCTU BIOA_MYCTU]] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.<ref>PMID:16984394</ref> | |||
==About this Structure== | |||
[[4mqq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQQ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024482078</ref><references group="xtra"/><references/> | |||
[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]] | |||
[[Category: Dai, R.]] | |||
[[Category: Finzel, B C.]] | |||
[[Category: Plp]] | |||
[[Category: Transaminase]] | |||
[[Category: Transferase]] | |||
Revision as of 09:10, 19 March 2014
Mycobaterium tuberculosis transaminase BioA complexed with benzo[d]thiazole-2-carbohydrazide
Template:ABSTRACT PUBMED 24482078
Function
[BIOA_MYCTU] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.[1]
About this Structure
4mqq is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Dai R, Wilson DJ, Geders TW, Aldrich CC, Finzel BC. Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides. Chembiochem. 2014 Mar 3;15(4):575-86. doi: 10.1002/cbic.201300748. Epub 2014 Jan , 31. PMID:24482078 doi:https://dx.doi.org/10.1002/cbic.201300748
- ↑ Mann S, Ploux O. 7,8-Diaminoperlargonic acid aminotransferase from Mycobacterium tuberculosis, a potential therapeutic target. Characterization and inhibition studies. FEBS J. 2006 Oct;273(20):4778-89. Epub 2006 Sep 19. PMID:16984394 doi:10.1111/j.1742-4658.2006.05479.x
