4n7q: Difference between revisions
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{{STRUCTURE_4n7q| PDB=4n7q | SCENE= }} | |||
===Crystal structure of eukaryotic THIC from A. thaliana=== | |||
{{ABSTRACT_PUBMED_24161603}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/THIC_ARATH THIC_ARATH]] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18048325</ref> <ref>PMID:18332905</ref> | |||
==About this Structure== | |||
[[4n7q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7Q OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024161603</ref><references group="xtra"/><references/> | |||
[[Category: Phosphomethylpyrimidine synthase]] | |||
[[Category: Begley, T P.]] | |||
[[Category: Coquille, S C.]] | |||
[[Category: Fitzpatrick, T B.]] | |||
[[Category: Mehta, A.]] | |||
[[Category: Roux, C.]] | |||
[[Category: Thore, S.]] | |||
[[Category: Hmp-p synthase]] | |||
[[Category: Lyase]] | |||
[[Category: Metal binding site]] | |||
[[Category: Sam radical dependent enzyme]] | |||
Revision as of 08:20, 13 November 2013
Crystal structure of eukaryotic THIC from A. thaliana
Template:ABSTRACT PUBMED 24161603
Function
[THIC_ARATH] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.[1] [2]
About this Structure
4n7q is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Coquille S, Roux C, Mehta A, Begley TP, Fitzpatrick TB, Thore S. High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. J Struct Biol. 2013 Oct 23. pii: S1047-8477(13)00270-0. doi:, 10.1016/j.jsb.2013.10.005. PMID:24161603 doi:https://dx.doi.org/10.1016/j.jsb.2013.10.005
- ↑ Raschke M, Burkle L, Muller N, Nunes-Nesi A, Fernie AR, Arigoni D, Amrhein N, Fitzpatrick TB. Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19637-42. Epub 2007 Nov 28. PMID:18048325 doi:https://dx.doi.org/10.1073/pnas.0709597104
- ↑ Kong D, Zhu Y, Wu H, Cheng X, Liang H, Ling HQ. AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana. Cell Res. 2008 May;18(5):566-76. doi: 10.1038/cr.2008.35. PMID:18332905 doi:https://dx.doi.org/10.1038/cr.2008.35
