2psu: Difference between revisions

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[[Image:2psu.jpg|left|200px]]<br /><applet load="2psu" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2psu.jpg|left|200px]]
caption="2psu, resolution 1.93&Aring;" />
 
'''Crystal Structure of wild type HIV-1 protease in complex with CARB-AD37'''<br />
{{Structure
|PDB= 2psu |SIZE=350|CAPTION= <scene name='initialview01'>2psu</scene>, resolution 1.93&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=MUU:N-[(1S,2R)-1-BENZYL-3-{(CYCLOPROPYLMETHYL)[(3-METHOXYPHENYL)SULFONYL]AMINO}-2-HYDROXYPROPYL]-N'-METHYLSUCCINAMIDE'>MUU</scene>
|ACTIVITY=
|GENE= pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal Structure of wild type HIV-1 protease in complex with CARB-AD37'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2PSU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=ACT:'>ACT</scene> and <scene name='pdbligand=MUU:'>MUU</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSU OCA].  
2PSU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PSU OCA].  


==Reference==
==Reference==
Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis., Chellappan S, Kiran Kumar Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Kairys V, Fernandes MX, Altman MD, Tidor B, Rana TM, Schiffer CA, Gilson MK, Chem Biol Drug Des. 2007 May;69(5):298-313. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17539822 17539822]
Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis., Chellappan S, Kiran Kumar Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Kairys V, Fernandes MX, Altman MD, Tidor B, Rana TM, Schiffer CA, Gilson MK, Chem Biol Drug Des. 2007 May;69(5):298-313. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17539822 17539822]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protease inhibitor]]
[[Category: protease inhibitor]]


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