2m0h: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===SP-B C-terminal (residues 59-80) peptide in methanol===

~~The~~ entry ~~2m0h~~ is ~~ON HOLD~~ ~~until Apr 24 2015~~

==Disease==

[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[http://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref> Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[http://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>

~~Authors~~: ~~Kuznetsova, A~~.~~, Long, J~~.R.

==Function==

[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

~~Description~~: SP-~~B C~~-~~terminal (residues 59-80) peptide in methanol~~

==About this Structure==

[[2m0h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0H OCA].

==Reference==

[[Category: Kuznetsova, A.]]

[[Category: Long, J R.]]

[[Category: Dodecylphosphocholine]]

[[Category: Micelle]]

[[Category: Peptide fragment]]

[[Category: Pulmonary surfactant-associated protein b]]

[[Category: Unknown function]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2m0h|  PDB=2m0h  |  SCENE=  }}
+===SP-B C-terminal (residues 59-80) peptide in methanol===
-The entry 2m0h is ON HOLD  until Apr 24 2015
+==Disease==
+[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1) [MIM:[http://omim.org/entry/265120 265120]]; also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.<ref>PMID:7491219</ref>   Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:[http://omim.org/entry/267450 267450]]. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.<ref>PMID:11063734</ref>
-Authors: Kuznetsova, A., Long, J.R.
+==Function==
+[[http://www.uniprot.org/uniprot/PSPB_HUMAN PSPB_HUMAN]] Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
-Description: SP-B C-terminal (residues 59-80) peptide in methanol
+==About this Structure==
+[[2m0h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0H OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Kuznetsova, A.]]
+[[Category: Long, J R.]]
+[[Category: Dodecylphosphocholine]]
+[[Category: Micelle]]
+[[Category: Peptide fragment]]
+[[Category: Pulmonary surfactant-associated protein b]]
+[[Category: Unknown function]]