2mcv: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2mcv| PDB=2mcv | SCENE= }} | |||
===Solid-state NMR structure of piscidin 1 in aligned 1:1 phosphatidylethanolamine/phosphoglycerol lipid bilayers=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MORO_MORSA MORO_MORSA]] Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores.<ref>PMID:11713517</ref> <ref>PMID:17253775</ref> | |||
==About this Structure== | |||
[[2mcv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCV OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Cotten, M L.]] | |||
[[Category: Fu, R.]] | |||
[[Category: Grant, C V.]] | |||
[[Category: Hayden, R M.]] | |||
[[Category: Pastor, R W.]] | |||
[[Category: Perrin, B S.]] | |||
[[Category: Tian, Y.]] | |||
[[Category: Amphipathic]] | |||
[[Category: Anti hiv-1]] | |||
[[Category: Anticancer peptide]] | |||
[[Category: Antimicrobial peptide]] | |||
[[Category: Antimicrobial protein]] | |||
[[Category: Bacterial cell membrane mimic]] | |||
[[Category: Cationic]] | |||
[[Category: Helical]] | |||
[[Category: Histidine rich]] | |||
[[Category: Lipid bilayer]] | |||
Revision as of 06:59, 22 January 2014
Solid-state NMR structure of piscidin 1 in aligned 1:1 phosphatidylethanolamine/phosphoglycerol lipid bilayers
Function
[MORO_MORSA] Exhibits broad spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria as well as against a variety of fungi. Has hemolytic activity. Seems to disrupt the membranes by adopting an alpha helical conformation and forming toroidal pores.[1] [2]
About this Structure
2mcv is a 1 chain structure. Full experimental information is available from OCA.
Reference
- ↑ Silphaduang U, Noga EJ. Peptide antibiotics in mast cells of fish. Nature. 2001 Nov 15;414(6861):268-9. PMID:11713517 doi:https://dx.doi.org/10.1038/35104690
- ↑ Campagna S, Saint N, Molle G, Aumelas A. Structure and mechanism of action of the antimicrobial peptide piscidin. Biochemistry. 2007 Feb 20;46(7):1771-8. Epub 2007 Jan 25. PMID:17253775 doi:10.1021/bi0620297
