4bx3: Difference between revisions
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{{STRUCTURE_4bx3| PDB=4bx3 | SCENE= }} | |||
===Crystal Structure of murine Chronophin (Pyridoxal Phosphate Phosphatase)=== | |||
{{ABSTRACT_PUBMED_24338687}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PLPP_MOUSE PLPP_MOUSE]] Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP (By similarity). | |||
==About this Structure== | |||
[[4bx3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BX3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024338687</ref><references group="xtra"/><references/> | |||
[[Category: Gohla, A.]] | |||
[[Category: Knobloch, G.]] | |||
[[Category: Schindelin, H.]] | |||
[[Category: Had phosphatase]] | |||
[[Category: Had-like hydrolase]] | |||
[[Category: Hydrolase]] | |||
[[Category: Pdxp]] | |||
Revision as of 10:16, 25 December 2013
Crystal Structure of murine Chronophin (Pyridoxal Phosphate Phosphatase)
Template:ABSTRACT PUBMED 24338687
Function
[PLPP_MOUSE] Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP (By similarity).
About this Structure
4bx3 is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Kestler C, Knobloch G, Tessmer I, Jeanclos E, Schindelin H, Gohla A. Chronophin dimerization is required for proper positioning of its substrate specificity loop. J Biol Chem. 2013 Dec 14. PMID:24338687 doi:https://dx.doi.org/10.1074/jbc.M113.536482
