4cay: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4cay|  PDB=4cay  |  SCENE=  }}
===Crystal structure of a human Anp32e-H2A.Z-H2B complex===


The entry 4cay is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref>  [[http://www.uniprot.org/uniprot/AN32E_HUMAN AN32E_HUMAN]] Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity (By similarity). [[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  


Authors: Diebold, M.-L., Marek, M., Romier, C.
==About this Structure==
[[4cay]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CAY OCA].  


Description: Crystal structure of a human Anp32e-H2A.Z-H2B complex
==Reference==
<references group="xtra"/><references/>
[[Category: Diebold, M L.]]
[[Category: Marek, M.]]
[[Category: Romier, C.]]
[[Category: Epigenetic]]
[[Category: Histone chaperone]]
[[Category: Histone variant]]
[[Category: Nucleosome]]
[[Category: Transcription]]
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