4cdj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of ZNRF3 ectodomain===

~~The entry 4cdj is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>

~~Authors~~: ~~Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C~~.M.~~, Clevers, H~~.~~, Gros, P~~.

==About this Structure==

[[4cdj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDJ OCA].

~~Description~~: ~~Structure of ZNRF3 ectodomain~~

==Reference==

[[Category: Clevers, H.]]

[[Category: Forneris, F.]]

[[Category: Granneman, J C.M.]]

[[Category: Gros, P.]]

[[Category: Lau, W de.]]

[[Category: Madoori, P K.]]

[[Category: Peng, W C.]]

[[Category: Adult stem cell]]

[[Category: E3 ligase]]

[[Category: Lgr5]]

[[Category: Ligase]]

[[Category: Protease-associated domain]]

[[Category: R-spondin]]

[[Category: Wnt signaling]]

[[Category: Zinc ring finger]]

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-'''Unreleased structure'''
+{{STRUCTURE_4cdj|  PDB=4cdj  |  SCENE=  }}
+===Structure of ZNRF3 ectodomain===
+{{ABSTRACT_PUBMED_24349440}}
-The entry 4cdj is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>
-Authors: Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P.
+==About this Structure==
+[[4cdj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CDJ OCA].
-Description: Structure of ZNRF3 ectodomain
+==Reference==
+<ref group="xtra">PMID:024349440</ref><references group="xtra"/><references/>
+[[Category: Clevers, H.]]
+[[Category: Forneris, F.]]
+[[Category: Granneman, J C.M.]]
+[[Category: Gros, P.]]
+[[Category: Lau, W de.]]
+[[Category: Madoori, P K.]]
+[[Category: Peng, W C.]]
+[[Category: Adult stem cell]]
+[[Category: E3 ligase]]
+[[Category: Lgr5]]
+[[Category: Ligase]]
+[[Category: Protease-associated domain]]
+[[Category: R-spondin]]
+[[Category: Wnt signaling]]
+[[Category: Zinc ring finger]]