4iio: Difference between revisions
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{{STRUCTURE_4iio| PDB=4iio | SCENE= }} | |||
===Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref> | |||
==About this Structure== | |||
[[4iio]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Dong, A.]] | |||
[[Category: Edwards, A M.]] | |||
[[Category: Gu, J.]] | |||
[[Category: Guan, X.]] | |||
[[Category: Huang, H.]] | |||
[[Category: SGC, Structural Genomics Consortium.]] | |||
[[Category: Sidhu, S.]] | |||
[[Category: Tempel, W.]] | |||
[[Category: Tong, Y.]] | |||
[[Category: Endocytosis]] | |||
[[Category: Itsn2]] | |||
[[Category: Protein-peptide complex]] | |||
[[Category: Sgc]] | |||
[[Category: Sh3 domain]] | |||
[[Category: Structural genomic]] | |||
[[Category: Structural genomics consortium]] | |||
[[Category: Synthetic peptide]] | |||
Revision as of 10:25, 25 December 2013
Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide
Function
[ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).[1] [2]
About this Structure
4iio is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Mettlen M, Stoeber M, Loerke D, Antonescu CN, Danuser G, Schmid SL. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell. 2009 Jul;20(14):3251-60. doi: 10.1091/mbc.E09-03-0256. Epub 2009, May 20. PMID:19458185 doi:10.1091/mbc.E09-03-0256
- ↑ Teckchandani A, Mulkearns EE, Randolph TW, Toida N, Cooper JA. The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16. doi: 10.1091/mbc.E11-12-1007. Epub 2012, May 30. PMID:22648170 doi:10.1091/mbc.E11-12-1007
