4m8o: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4m8o| PDB=4m8o | SCENE= }} | |||
===TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DPOE_YEAST DPOE_YEAST]] DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.<ref>PMID:12124389</ref> | |||
==About this Structure== | |||
[[4m8o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8O OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: DNA-directed DNA polymerase]] | |||
[[Category: Hogg, M.]] | |||
[[Category: Johansson, E.]] | |||
[[Category: Osterman, P.]] | |||
[[Category: Sauer-Eriksson, A E.]] | |||
[[Category: Dna polymerase b type]] | |||
[[Category: Dna replication]] | |||
[[Category: Dna synthesis]] | |||
[[Category: Metal-binding]] | |||
[[Category: Nucleotidyltransferase]] | |||
[[Category: Protein-dna complex]] | |||
[[Category: Transferase dna complex]] | |||
[[Category: Transferase-dna complex]] | |||
Revision as of 10:34, 27 November 2013
TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP
Function
[DPOE_YEAST] DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.[1]
About this Structure
4m8o is a 3 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Shimizu K, Hashimoto K, Kirchner JM, Nakai W, Nishikawa H, Resnick MA, Sugino A. Fidelity of DNA polymerase epsilon holoenzyme from budding yeast Saccharomyces cerevisiae. J Biol Chem. 2002 Oct 4;277(40):37422-9. Epub 2002 Jul 17. PMID:12124389 doi:https://dx.doi.org/10.1074/jbc.M204476200
