4n7m: Difference between revisions
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{{STRUCTURE_4n7m| PDB=4n7m | SCENE= }} | |||
===Tailoring Small Molecules for an Allosteric Site on Procaspase-6=== | |||
{{ABSTRACT_PUBMED_24259468}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | |||
==About this Structure== | |||
[[4n7m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7M OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024259468</ref><references group="xtra"/><references/> | |||
[[Category: Caspase-6]] | |||
[[Category: Murray, J M.]] | |||
[[Category: Steffek, M]] | |||
[[Category: Allosteric]] | |||
[[Category: Caspase-6 zymogen]] | |||
[[Category: Cysteine protease]] | |||
[[Category: Hydrolase]] | |||
[[Category: Procaspse-6]] | |||
[[Category: Structure based drug design]] | |||
Revision as of 10:18, 18 December 2013
Tailoring Small Molecules for an Allosteric Site on Procaspase-6
Template:ABSTRACT PUBMED 24259468
Function
[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
About this Structure
4n7m is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring Small Molecules for an Allosteric Site on Procaspase-6. ChemMedChem. 2013 Nov 20. doi: 10.1002/cmdc.201300424. PMID:24259468 doi:https://dx.doi.org/10.1002/cmdc.201300424
