4n9y: Difference between revisions
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{{STRUCTURE_4n9y| PDB=4n9y | SCENE= }} | |||
===Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E748Q=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PARG_MOUSE PARG_MOUSE]] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity). | |||
==About this Structure== | |||
[[4n9y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9Y OCA]. | |||
[[Category: Cheng, Z.]] | |||
[[Category: Wang, Z.]] | |||
[[Category: Xu, W.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Parg]] | |||
Revision as of 07:50, 29 January 2014
Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain mutant E748Q
Function
[PARG_MOUSE] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (By similarity).
About this Structure
4n9y is a 1 chain structure. Full crystallographic information is available from OCA.
