2q1j: Difference between revisions

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[[Image:2q1j.jpg|left|200px]]<br /><applet load="2q1j" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2q1j.jpg|left|200px]]
caption="2q1j, resolution 1.90&Aring;" />
 
'''The discovery of glycine and related amino acid-based factor xa inhibitors'''<br />
{{Structure
|PDB= 2q1j |SIZE=350|CAPTION= <scene name='initialview01'>2q1j</scene>, resolution 1.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=FXI:1-(butyl{[(4-chlorophenyl)amino]carbonyl}amino)-N-[3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl]cyclopropanecarboxamide'>FXI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6]
|GENE=
}}
 
'''The discovery of glycine and related amino acid-based factor xa inhibitors'''
 


==Overview==
==Overview==
Line 10: Line 19:


==About this Structure==
==About this Structure==
2Q1J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=FXI:'>FXI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1J OCA].  
2Q1J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q1J OCA].  


==Reference==
==Reference==
The discovery of glycine and related amino acid-based factor Xa inhibitors., Kohrt JT, Filipski KJ, Cody WL, Bigge CF, La F, Welch K, Dahring T, Bryant JW, Leonard D, Bolton G, Narasimhan L, Zhang E, Peterson JT, Haarer S, Sahasrabudhe V, Janiczek N, Desiraju S, Hena M, Fiakpui C, Saraswat N, Sharma R, Sun S, Maiti SN, Leadley R, Edmunds JJ, Bioorg Med Chem. 2006 Jul 1;14(13):4379-92. Epub 2006 Mar 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16529937 16529937]
The discovery of glycine and related amino acid-based factor Xa inhibitors., Kohrt JT, Filipski KJ, Cody WL, Bigge CF, La F, Welch K, Dahring T, Bryant JW, Leonard D, Bolton G, Narasimhan L, Zhang E, Peterson JT, Haarer S, Sahasrabudhe V, Janiczek N, Desiraju S, Hena M, Fiakpui C, Saraswat N, Sharma R, Sun S, Maiti SN, Leadley R, Edmunds JJ, Bioorg Med Chem. 2006 Jul 1;14(13):4379-92. Epub 2006 Mar 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16529937 16529937]
[[Category: Coagulation factor Xa]]
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: blood coagulation]]
[[Category: blood coagulation]]
[[Category: calcium]]
[[Category: calcium]]
[[Category: cleavage on pair of basic residues]]
[[Category: cleavage on pair of basic residue]]
[[Category: coagulation fxa]]
[[Category: coagulation fxa]]
[[Category: egf-like domain]]
[[Category: egf-like domain]]
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[[Category: zymogen]]
[[Category: zymogen]]


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