4neu: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===X-ray structure of Receptor Interacting Protein 1 (RIP1)kinase domain with a 1-aminoisoquinoline inhibitor===

~~The entry 4neu is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/RIPK1_HUMAN RIPK1_HUMAN]] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.<ref>PMID:11101870</ref> <ref>PMID:19524513</ref> <ref>PMID:19524512</ref>

~~Authors~~: ~~Nolte, R.T., Ward, P~~.~~, kahler, K~~. M.~~, Campobasso, N~~.

==About this Structure==

[[4neu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEU OCA].

~~Description~~: X-~~ray structure of Receptor Interacting Protein 1 (RIP1)~~kinase ~~domain with a 1-aminoisoquinoline inhibitor~~

==Reference==

[[Category: Non-specific serine/threonine protein kinase]]

[[Category: Campobasso, N.]]

[[Category: Nolte, R T.]]

[[Category: Ward, P.]]

[[Category: Kahler, K M.]]

[[Category: Atp binding]]

[[Category: Kinase]]

[[Category: Phosphorylation]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4neu|  PDB=4neu  |  SCENE=  }}
+===X-ray structure of Receptor Interacting Protein 1 (RIP1)kinase domain with a 1-aminoisoquinoline inhibitor===
-The entry 4neu is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/RIPK1_HUMAN RIPK1_HUMAN]] Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.<ref>PMID:11101870</ref> <ref>PMID:19524513</ref> <ref>PMID:19524512</ref>
-Authors: Nolte, R.T., Ward, P., kahler, K. M., Campobasso, N.
+==About this Structure==
+[[4neu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEU OCA].
-Description: X-ray structure of Receptor Interacting Protein 1 (RIP1)kinase domain with a 1-aminoisoquinoline inhibitor
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Campobasso, N.]]
+[[Category: Nolte, R T.]]
+[[Category: Ward, P.]]
+[[Category: Kahler, K M.]]
+[[Category: Atp binding]]
+[[Category: Kinase]]
+[[Category: Phosphorylation]]
+[[Category: Transferase]]