4c50: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4c50]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C50 OCA]. | [[4c50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_sp._h37rv Mycobacterium sp. h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C50 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024185282</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024185282</ref><references group="xtra"/><references/> | ||
[[Category: Catalase peroxidase]] | [[Category: Catalase peroxidase]] | ||
[[Category: Mycobacterium sp. h37rv]] | |||
[[Category: Andersson, K K.]] | [[Category: Andersson, K K.]] | ||
[[Category: Hersleth, H P.]] | [[Category: Hersleth, H P.]] | ||
Revision as of 09:00, 27 November 2013
Crystal Structure of the Catalase-Peroxidase (KatG) D137S mutant from Mycobacterium Tuberculosis
Template:ABSTRACT PUBMED 24185282
Function
[KATG_MYCTU] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.[1]
About this Structure
4c50 is a 2 chain structure with sequence from Mycobacterium sp. h37rv. Full crystallographic information is available from OCA.
Reference
- Zhao X, Hersleth HP, Zhu J, Andersson KK, Magliozzo RS. Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid. Chem Commun (Camb). 2013 Nov 4. PMID:24185282 doi:https://dx.doi.org/10.1039/c3cc47022a
