2q7f: Difference between revisions
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'''Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site''' | {{Structure | ||
|PDB= 2q7f |SIZE=350|CAPTION= <scene name='initialview01'>2q7f</scene>, resolution 2.49Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= yrrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis]) | |||
}} | |||
'''Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2Q7F is a [ | 2Q7F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7F OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site., Han D, Oh J, Kim K, Lim H, Kim Y, Biochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5. PMID:[http:// | Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site., Han D, Oh J, Kim K, Lim H, Kim Y, Biochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17624311 17624311] | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: yrrb]] | [[Category: yrrb]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:22:44 2008'' | ||
Revision as of 16:22, 20 March 2008
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| 2q7f, resolution 2.49Å | |||||||||||||
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| Gene: | yrrB (Bacillus subtilis) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site
Overview
YrrB is a hypothetical protein containing a tetratricopeptide repeat (TPR) domain from a Gram-positive bacterium, Bacillus subtilis. We determined YrrB structure in the C2 space group to 2.5A resolution, which is the first TPR structure of the Gram-positive bacterium B. subtilis. In contrast to other known TPR structures, the concave surface of the YrrB TPR domain is composed of the putative peptide-binding pocket lined with positively-charged residues. This unique charge distribution reveals that YrrB can interact with partner proteins via an unusual TPR-mediated interaction mode, compared to that of other TPR-containing structures. Functional annotation using genomics analysis suggested that YrrB may be an interacting mediator in the complex formation among RNA sulfuration components. No proteins containing a TPR domain have been identified in the biosynthesis of sulfur-containing biomolecules. Thus, YrrB could play a new role as a connecting module among those proteins in the conserved gene cluster for RNA sulfuration.
About this Structure
2Q7F is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site., Han D, Oh J, Kim K, Lim H, Kim Y, Biochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5. PMID:17624311
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