2q9m: Difference between revisions

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[[Image:2q9m.jpg|left|200px]]<br /><applet load="2q9m" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2q9m.jpg|left|200px]]
caption="2q9m, resolution 2.05&Aring;" />
 
'''4-Substituted Trinems as Broad Spectrum-Lactamase Inhibitors: Structure-based Design, Synthesis and Biological Activity'''<br />
{{Structure
|PDB= 2q9m |SIZE=350|CAPTION= <scene name='initialview01'>2q9m</scene>, resolution 2.05&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=LK7:(1R,4S,7AS)-1-(1-FORMYLPROP-1-EN-1-YL)-4-METHOXY-2,4,5,6,7,7A-HEXAHYDRO-1H-ISOINDOLE-3-CARBOXYLIC ACID'>LK7</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]
|GENE=
}}
 
'''4-Substituted Trinems as Broad Spectrum-Lactamase Inhibitors: Structure-based Design, Synthesis and Biological Activity'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2Q9M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae] with <scene name='pdbligand=LK7:'>LK7</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9M OCA].  
2Q9M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9M OCA].  


==Reference==
==Reference==
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity., Plantan I, Selic L, Mesar T, Anderluh PS, Oblak M, Prezelj A, Hesse L, Andrejasic M, Vilar M, Turk D, Kocijan A, Prevec T, Vilfan G, Kocjan D, Copar A, Urleb U, Solmajer T, J Med Chem. 2007 Aug 23;50(17):4113-21. Epub 2007 Aug 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17665896 17665896]
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity., Plantan I, Selic L, Mesar T, Anderluh PS, Oblak M, Prezelj A, Hesse L, Andrejasic M, Vilar M, Turk D, Kocijan A, Prevec T, Vilfan G, Kocjan D, Copar A, Urleb U, Solmajer T, J Med Chem. 2007 Aug 23;50(17):4113-21. Epub 2007 Aug 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17665896 17665896]
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Enterobacter cloacae]]
[[Category: Enterobacter cloacae]]
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[[Category: tricyclic carbapenem]]
[[Category: tricyclic carbapenem]]


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