4cem: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4cem|  PDB=4cem  |  SCENE=  }}
===Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2===
{{ABSTRACT_PUBMED_24271394}}


The entry 4cem is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/RENT2_HUMAN RENT2_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.<ref>PMID:11163187</ref> <ref>PMID:16209946</ref> <ref>PMID:18066079</ref> 


Authors: Clerici, M., Deniaud, A., Boehm, V., Gehring, N.H., Schaffitzel, C., Cusack, S.
==About this Structure==
[[4cem]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CEM OCA].  


Description: Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2
==Reference==
<ref group="xtra">PMID:024271394</ref><references group="xtra"/><references/>
[[Category: Boehm, V.]]
[[Category: Clerici, M.]]
[[Category: Cusack, S.]]
[[Category: Deniaud, A.]]
[[Category: Gehring, N H.]]
[[Category: Schaffitzel, C.]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/4cem"