4gmb: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of human WD repeat domain 5 with compound MM-402===

~~The entry 4gmb~~ is ~~ON HOLD~~ ~~until Feb 19 2015~~

==Function==

[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>

~~Authors~~: ~~Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L~~.~~, Lei, M~~.~~, Dou, Y~~.~~, Wang, S~~.

==About this Structure==

[[4gmb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMB OCA].

~~Description~~: ~~Crystal structure of human WD repeat domain 5 with compound MM~~-~~402~~

==Reference==

[[Category: Bernard, D.]]

[[Category: Cao, F.]]

[[Category: Chen, Y.]]

[[Category: Dou, Y.]]

[[Category: Karatas, H.]]

[[Category: Lei, M.]]

[[Category: Liu, L.]]

[[Category: Townsend, E C.]]

[[Category: Wang, S.]]

[[Category: Histone methyltransferase]]

[[Category: Mll1]]

[[Category: Transcription-transcription inhibitor complex]]

[[Category: Wd40]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4gmb|  PDB=4gmb  |  SCENE=  }}
+===Crystal structure of human WD repeat domain 5 with compound MM-402===
-The entry 4gmb is ON HOLD  until Feb 19 2015
+==Function==
+[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
-Authors: Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
+==About this Structure==
+[[4gmb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMB OCA].
-Description: Crystal structure of human WD repeat domain 5 with compound MM-402
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Bernard, D.]]
+[[Category: Cao, F.]]
+[[Category: Chen, Y.]]
+[[Category: Dou, Y.]]
+[[Category: Karatas, H.]]
+[[Category: Lei, M.]]
+[[Category: Liu, L.]]
+[[Category: Townsend, E C.]]
+[[Category: Wang, S.]]
+[[Category: Histone methyltransferase]]
+[[Category: Mll1]]
+[[Category: Transcription-transcription inhibitor complex]]
+[[Category: Wd40]]