4m9e: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA===

~~The entry 4m9e is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/KLF4_MOUSE KLF4_MOUSE]] Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).<ref>PMID:10556311</ref> <ref>PMID:10431239</ref> <ref>PMID:15358627</ref> <ref>PMID:16954384</ref> <ref>PMID:17060454</ref> <ref>PMID:19816951</ref> <ref>PMID:20071344</ref>

~~Authors~~: ~~Liu, Y., Olanrewaju, Y.O., Blumenthal, R~~.M.~~, Zhang, X~~.~~, Cheng, X~~.

==About this Structure==

[[4m9e]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9E OCA].

~~Description~~: ~~Structure of Klf4~~ zinc finger ~~DNA~~ binding ~~domain in~~ complex ~~with methylated DNA~~

==Reference==

[[Category: Blumenthal, R M.]]

[[Category: Cheng, X.]]

[[Category: Liu, Y.]]

[[Category: Olanrewaju, Y O.]]

[[Category: Zhang, X.]]

[[Category: C2h2 zinc finger]]

[[Category: Cellular reprogramming]]

[[Category: Dna binding]]

[[Category: Dna methylation]]

[[Category: Transcription factor]]

[[Category: Transcription-dna complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4m9e|  PDB=4m9e  |  SCENE=  }}
+===Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA===
-The entry 4m9e is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/KLF4_MOUSE KLF4_MOUSE]] Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).<ref>PMID:10556311</ref> <ref>PMID:10431239</ref> <ref>PMID:15358627</ref> <ref>PMID:16954384</ref> <ref>PMID:17060454</ref> <ref>PMID:19816951</ref> <ref>PMID:20071344</ref>
-Authors: Liu, Y., Olanrewaju, Y.O., Blumenthal, R.M., Zhang, X., Cheng, X.
+==About this Structure==
+[[4m9e]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9E OCA].
-Description: Structure of Klf4 zinc finger DNA binding domain in complex with methylated DNA
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Blumenthal, R M.]]
+[[Category: Cheng, X.]]
+[[Category: Liu, Y.]]
+[[Category: Olanrewaju, Y O.]]
+[[Category: Zhang, X.]]
+[[Category: C2h2 zinc finger]]
+[[Category: Cellular reprogramming]]
+[[Category: Dna binding]]
+[[Category: Dna methylation]]
+[[Category: Transcription factor]]
+[[Category: Transcription-dna complex]]