4nbo: Difference between revisions
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{{STRUCTURE_4nbo| PDB=4nbo | SCENE= }} | |||
===Human steroid receptor RNA activator protein carboxy-terminal domain=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SRA1_HUMAN SRA1_HUMAN]] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.<ref>PMID:10199399</ref> <ref>PMID:12943696</ref> <ref>PMID:14517287</ref> <ref>PMID:15351741</ref> <ref>PMID:15147866</ref> | |||
==About this Structure== | |||
[[4nbo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NBO OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Barthel, K K.B.]] | |||
[[Category: Cech, T C.]] | |||
[[Category: Mckay, D B.]] | |||
[[Category: Xi, L.]] | |||
[[Category: 5-helix bundle]] | |||
[[Category: Transcription]] | |||