2qcl: Difference between revisions

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[[Image:2qcl.jpg|left|200px]]<br /><applet load="2qcl" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2qcl.jpg|left|200px]]
caption="2qcl, resolution 1.85&Aring;" />
 
'''Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to OMP'''<br />
{{Structure
|PDB= 2qcl |SIZE=350|CAPTION= <scene name='initialview01'>2qcl</scene>, resolution 1.85&Aring;
|SITE= <scene name='pdbsite=AC1:Omp+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Omp+Binding+Site+For+Residue+B+2'>AC2</scene> and <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+A+501'>AC3</scene>
|LIGAND= <scene name='pdbligand=OMP:OROTIDINE-5'-MONOPHOSPHATE'>OMP</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23]
|GENE= UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of the orotidine-5'-monophosphate decarboxylase domain (Asp312Asn mutant) of human UMP synthase bound to OMP'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2QCL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=OMP:'>OMP</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] Known structural/functional Sites: <scene name='pdbsite=AC1:Omp+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Omp+Binding+Site+For+Residue+B+2'>AC2</scene> and <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+A+501'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCL OCA].  
2QCL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCL OCA].  


==Reference==
==Reference==
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design., Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG, Structure. 2008 Jan;16(1):82-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18184586 18184586]
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design., Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG, Structure. 2008 Jan;16(1):82-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18184586 18184586]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: ump synthase]]
[[Category: ump synthase]]


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